First report on orally administered methadone to multi-drug resistance (MDR1) gene normal horses

Expression of multidrug resistance gene (MDR1) in normal hematopoietic cells.

Expression of multi drug resistance (MDR1) gene in human promyelocytic leukemia cell line selected with vincristine

MDR1 mediated drug resistance is one of the main problems for some cancer chemotherapies. Vincristine (VCR) is an effective drug used in clinical treatment of acute leukemias. The concentration of VCR was stepwise increased (1-50 nM) in the cell culture media of HL60 cells (AML cell line). The viability of cells was determined and the expression of MDR1 gene was studied by using reverse transcr...

Multi - drug resistance gene ( MDR 1 ) and opioid analgesia in horses

Opioid absorption in the intestinal tract as well as its effects in the central nervous system is modulated by the Pglycoprotein (P-gp) encoded in the Multi-drug Resistance gene (MDR1) also named ATP-binding cassete, subfamily B, member 1 (ABCB1). This MDR1 gene acts as a selective pump. The expression of this protein in humans and rodents inhibits cellular uptake of substrate opioids. The pres...

Absorption of orally administered nafcillin in normal healthy volunteers.

The absorption of orally administered nafcillin sodium monohydrate buffered with calcium carbonate was studied in 10 healthy human volunteers. Dosages of 500 mg and 1 g were studied in fasting and nonfasting states. There was considerable individual variation in the absorption of nafcillin, although measurable serum concentrations were obtained in all subjects. With few exceptions, peak serum c...

Orally administered liposomal formulations for colon targeted drug delivery

Colon targeted drug delivery is an active area of research for diseases affecting the colon, as it shows promise in improving the efficacy of therapeutics and reducing systemic toxicity. Improved oral drug delivery design has unequivocally improved the bioavailability of drugs to the colon. The oral route of administration is the most common method of drug delivery. It is the preferred route of...